On 16 Aug,2020, Malaysia Health Ministry announced that D614G, a mutation of SARS-CoV-2 virus which causes coronavirus, has been detected in a minimum of three of the 45 cases during a cluster that started from a restaurant owner coming back from India and breached his 14-day home quarantine.
The D614G mutation was first detected in February in Europe and since then has become the dominant variant of SARS-CoV-2, found in swab samples across the planet . As per some researchers, the mutation is deemed to possess given the virus some quite biological edge enabling its global spread. Here is all you would like to understand about D614G:
What is D614G
Sars-Cov-2 is that the official name of the virus that causes the disease Coronavirus. And D614G may be a mutation of Sars-Cov-2. D614G is situated within the protein making up the virus’s “spike” it uses to interrupt into our cells. This mutation changes the aminoalkanoic acid at position 614, from D (aspartic acid) to G (glycine) so, D-614-G.
Sars-Cov-2 has undergone several mutations since the pandemic emerged in December 2019. However, just one of those mutations has thus far been singled out as possibly altering Sars-Cov-2 behaviour, namely D614G.
How does a variant becomes dominant
Dr. Bette Korber, a computational biologist & population geneticist said that the very fact the D614G variant now appears to be dominant everywhere, including in China, indicates it’s going to became better at spreading between people than the 1st version. Whenever the 2 versions were in circulation at an equivalent time, the new variant took over.
In his research paper published in July, Dr Korber had said that the D614G variant is so dominant, it’s now the pandemic. And it’s been for a few time – maybe even since the beginning of the epidemic in places just like the UK and therefore the East Coast of the US. So, while evidence is mounting that this mutation isn’t neutral, it doesn’t necessarily change how we should always believe the virus and its spread, he wrote.
Does D614G increase Covid-19 transmissibility
In lab tests conducted by Scripps University in Florida, the mutated virus was better at entering human cells than those without the variation. Changes to the spike protein the virus uses to latch on to human cells seem to permit it to “stick together better and performance more efficiently”, explained the researchers.
In another study conducted by the New York Genome Center and New York University, the researchers said that their findings point to the mutated virus being more transmissible than the first version “at least within the lab” but said it remains unclear how representative the lab results are of transmission in real patients.
Two studies published in Cell, by Dr. Korber and second study by WHO Collaborating Center in China, too gave similar outcomes that D164G, the dominant strain of SARS-CoV-2 seems to be 10-times more infectious than the first Wuhan-1 strain.
However, Cell also published a search review in July, by Dr Nathan D. Grubaugh, an professor of Epidemiology of Microbial Diseases at Yale School of Public Health who remarked that such studies suggest, but not prove increased viral transmissibility.
Can mutation impact vaccine research
Earlier is was speculated if we’ll got to develop separate vaccines for various variants. However, most of the vaccines in development are supported a special region of the spike so this could not have an impression on their development.
Although the D614G mutation happens within the viral spike protein, it doesn’t change the Receptor-Binding Domain (RBD) at the tip of the spike protein The RBD binds to the ACE2 receptor on human cells; it’s also the most target of the system . In essence, the D614G mutation alters the spike protein, but not the critical RBD immunogenic part.